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The copper ion confers catalytic activity: GHK acts as a copper chaperone, delivering Cu²⁺ to cuproenzymes including superoxide dismutase 1 (SOD1), cytochrome c oxidase (Complex IV), lysyl oxidase (LOX), and ceruloplasmin

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In contrast, no clastogenicity was noted at a dose of 750 mg/kg/day (1.8-times the MHDD, based on a body surface area comparison), suggesting a threshold effect