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Studies note that copper peptides have "a long history of safe use in wound healing and skin care" and are active at very low concentrations

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Gene Expression Regulation: Research using gene array analysis has reported that GHK-Cu influences the expression of over 4,000 human genes in cellular models — including broad upregulation of tissue repair, antioxidant defence, and anti-inflammatory genes, and downregulation of genes associated with inflammation and oxidative stress — making it one of the most extensively gene-profiled small peptides in biomedical research