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Drug class • Angiotensin II Receptor Blocker (ARB) Mechanism of action • Blocks AT₁ receptors for angiotensin II • Prevents: • Vasoconstriction • Aldosterone secretion • Sodium and water retention • Results in vasodilation and reduced blood pressure Clinical uses • Hypertension • Diabetic nephropathy • Heart failure (alternative to ACE inhibitors) • Stroke risk reduction in hypertension with LVH Pharmacokinetics • Losartan itself is active • Has an active metabolite (EXP-3174) which is more potent • Hepatic metabolism (CYP2C9, CYP3A4) • Once-daily dosing 👉 Important: Presence of an active metabolite does not make losartan a prodrug Adverse effects • Dizziness • Hyperkalemia • Hypotension • Rare: angioedema (less than ACE inhibitors) Contraindications • Pregnancy • Bilateral renal artery stenosis • Losartan = Active drug • Enalapril = Prodrug • ARBs do NOT cause cough (unlike ACE inhibitors) To view or add a comment, sign in Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation