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doi:10.1007/s00106-016-0330-8 Freire AO, Sugai GC, Chrispin FS, et al

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Current research hotspots involve developing derivatives with improved pharmacokinetic properties based on these lead compounds, or utilizing advanced drug delivery systems like nanoparticles, hydrogenated coconut oil microspheres, and degradable hydrogels to enhance their targeted delivery efficiency and therapeutic index (Table 1)