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In one RCT study, the use of multi-strain probiotics downregulated gene expression of interleukin-1 (IL-1), IL-8 and tumour necrosis factor α (TNF-α), whereas upregulated transforming growth factor beta (TGF-β) and peroxisome proliferator activated receptor gamma (PPAR-γ) in peripheral blood mononuclear cells (PBMC) of PD patients [114]
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