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The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins

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Thus, although negative selection against VAMP1 reduces cleavage on SNARE targets, evolution on procaspase-1 appears to confer caspase-like substrate preferences that include IL-1β or substrates with complete homology to the P2–P4′ of procaspase-1 such as ORC1 (residues 691–707)

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