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[14] In documented biotin deficiencies, improvements in symptoms like skin rash or hair loss can be observed within a few weeks of consistent therapy (exact timing can vary depending on the severity of deficiency and individual factors)
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Our observation that the maternally derived pool of B 12 in Gif –/– (F1) mice was sufficient to support their postnatal growth and bone mass until adulthood provided us with a model wherein we can use aged F1 mice to dissociate the effect of maternal B 12 on bone mass from its effect on growth
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