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Incretin mimetics, which regulate blood sugar and appetite levels, with applications in diabetes and obesity management [17]

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Specifically, IGF-I can increase the number of CD4 + CD8 + immature T cells in rat thymus and spleen [162], promotes T cell survival [163], proliferation, chemotaxis and maturation, and blocks spontaneous and induced programmed cell death [163,164], although it has also been reported to block IL-2-dependent lymphocyte growth and function [165]

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