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Neurodegenerative diseases Similar to muscle diseases, neurodegenerative conditions present altered mitochondrial homeostasis and NAD + metabolism, which have been thoroughly investigated as targets for NAD + modulation-based approaches 13,268,269

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In step (d) of the process, an alkali, an alkaline salt or a buffer system can optionally be added to the aqueous suspension from step (c) in order to adjust a pH of between pH 3.0 and pH 9.0