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The results showed that exercise and yoga as adjunctive treatments could mildly reduce depression levels compared to controls, while Tai Chi lacked sufficient evidence to support its effect (Seshadri et al., 2020)

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Given the evidence that activation of the neuroendocrine stress axis can alter redox balance 15,55,56 , we speculate that an excessive release of glucocorticoids altered oxidative stress and antioxidant levels in the brain by increasing ROS production, leading to higher glutathione ratios and DNA damage 53