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ATL2 is involved in abnormally elevated ER-mitochondria contacts in H4 PS1M146V cell line after PS1 mutant induction Among 26 DEGS related to ER, we focused on Atl2 , which was the most upregulated ER-related genes in PS1M146V knock-in mice

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As a result, scaling successful findings in mouse models to clinical human trials is often met with unfavorable outcomes [24]

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