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Due to the continuous efforts to enhance PROTAC technology, PROTACs have the potential to be an alternative drug discovery approach to compliment traditional cancer therapies and to combat treatment resistance

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Cells lacking PCBP1 or PCBP2 exhibit loss of DOHH activity, as measured by the accumulation of partially modified deoxyhypusine and reduced levels of fully modified hypusine (20% of control) in living cells