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a , b , Quantification of NETs formation in WT and XKR8 KO BMNs treated with PMA (100 nM, 6 h) in RPMI 1640 or Ca 2+ -free HBSS ( n = 10) ( a ), or in the presence of BAPTA-AM (25 μM, n = 10) ( b )

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These cases show that both placebo and real biologic responses are part of the picture