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α-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia
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Size:10mg Nasal Spray
Regulatory Status What It Means Clinical Impact for Physicians Category 2 Removal The substance is no longer flagged for “significant safety risks” preventing all use
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