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Ocrelizumab (Ocrevus) The drug can also increase your risk for various infections and other issues, including: Lower respiratory tract infections Upper respiratory tract infections Skin infections Herpes Hepatitis B (reactivated if you were previously treated for it) Progressive multifocal leukoencephalopathy (PML), a rare but life-threatening brain infection caused by the John Cunningham virus Cancer, including breast cancer Colitis (colon inflammation) Ublituximab (Briumvi) and Rituximab (Rituxan) Natalizumab (Tysabri) Natalizumab (Tysabri) is a lab-made monoclonal antibody that blocks immune cells from passing through the blood-brain barrier into the central nervous system, reducing inflammation