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Examples of neural tube defects include: spina bifida – where the baby's spine does not develop properly anencephaly – where a baby is born without parts of the brain and skull encephalocele – where a membrane or skin-covered sac containing part of the brain pushes out of a hole in the skull Effects of nitrous oxide Nitrous oxide, commonly known as ‘gas and air’, is a type of anaesthetic used in dental treatments and childbirth