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The conversion of methylmalonyl CoA to succinyl-CoA involves adenosylcobalamin as a cofactor, and a deficiency of this enzyme leads to an accumulation of methylmalonic acid
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126,127 By the early 1980s, acetaminophen had effectively replaced the analgesic phenacetin, which is metabolized to acetaminophen by the body 128,129 and which had been widely used since the late 1800s despite its carcinogenic and toxic nature
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