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Inducers of CYP3A4 The concomitant use of hydrocodone bitartrate and acetaminophen tablets and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of hydrocodone (see CLINICAL PHARMACOLOGY), resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to hydrocodone (see WARNINGS)

OCT24

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Kah-Leong LIM (Department of Physiology, National University of Singapore) for the HA-Ub (WT, K48 and K63) plasmids and members of the Kiuchi Laboratory for helpful discussion