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Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide

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In this system, the DNA damage detected in the absence of the Fanconi Anaemia DNA repair pathway is comparable to the damage detected by incubating cells with 0.5 mmol L −1 FA, which is close to the level reported for cellular GSH