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In its function as a cellular “caretaker”, attenuation of GSTP1 expression or activity by either genetic (e.g., deletion or mutation) or epigenetic alterations may reduce cellular detoxification capacity ( Figure 2 )
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The quercetin-mediated suppression of PCC proliferation, migration, and invasion was abrogated when the SHH activity was increased using recombinant Shh protein
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