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These findings have revealed that NAD+ serves not only as a metabolic cofactor but also as a critical regulator of epigenetic information, linking cellular energy status to long-term gene expression patterns and cellular identity

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Liraglutide (Victoza) was approved in 2010, followed by Saxenda (for weight loss) in 2014.33 Semaglutide (Ozempic) was approved in 2017, Wegovy (for weight loss) in 2021, and Rybelsus (oral) shortly thereafter