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doi: 10.1016/j.ajp.2019.101868

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451 In postmortem brain specimens, there were no transcription differences between MDD men and controls, and the levels of 5-HT 1D receptors and the transcription factors NUDR and REST, which regulate 5-HT activity, in 5-HT-containing neurons in the ventral raphe nuclei were found to be higher in MDD females

is made up of highly conserved domains such as two Rossmann fold domains