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In these analogues, a disulfide or lactam bridge was used as a conformational constraint of pharmacophore tetrapeptide His-DPhe-Arg-Trp to enhance the β-turn spanning His 6 and D-Phe 7 , while the pharmacophore group in Arg 8 was mimicked via N-α-alkylation of residues 8 or 9 with the guanidinylbutyl group
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Size:4 fl oz
doi: 10.1007/s004300050071 28 BalinB
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