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Reduced sarcoplasmic reticulum Ca2b-ATPase (SERCA2b) expression and activity (Janczewski and Lakatta, 2010), with a compensatory increase in the levels of the Na + /Ca 2+ exchanger, have been reported in hearts of old mice

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It activates the Notch signaling pathway to promote new blood vessel formation and modulates systemic inflammation by inhibiting NF-κB