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Based on the kinetic analyses, the 12-h time point was selected for subsequent experiments, as it demonstrated a dynamic range in LDH release, Caspase 3/7 activity, and IL-8 production
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Its core pathological feature is excessive accumulation of adipose tissue, accompanied by abnormal proliferation, differentiation, and metabolic dysfunction of adipocytes, which in turn induce a series of complications including insulin resistance, non‑alcoholic fatty liver disease, and cardiovascular diseases
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