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TGF-β1 derived from oligodendrocyte progenitor cells can activate the MEK/ERK signaling pathway in ECs to promote tight junction protein expression and improve BBB integrity, and knockout of Tgfbr1 in oligodendrocyte progenitor cells leads to cerebral hemorrhage and disruptive BBB in mice ( Several neural progenitors have also been shown to play important roles in brain region-specific angiogenesis via TGF-β signaling

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Epigenetic and chromatin regulation of C